The effects of methylene blue on adhesion formation in a rat model of experimental peritonitis.
Ulus Travma Acil Cerrahi Derg
; 17(3): 205-9, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21935796
ABSTRACT
BACKGROUND:
We investigated the effects of methylene blue (MB) on the early and late phases of adhesion and abscess formation in a standard colonic wall injury and fecal peritonitis model in rats.METHODS:
There were four groups Group I (only laparotomy, n=10), Group II (peritonitis + MB, n=15), Group III (peritonitis + saline, n=15), and Group IV (colon incision + saline, n=15). Mortality, morbidity, adhesion scores, histopathologic analyses, serum tumor necrosis factor-alpha (TNF-?) levels, and tissue hydroxyproline (5-HP) levels were evaluated in all animals. Descriptive statistical methods were used with Kruskal-Wallis test. When a statistical difference was obtained between groups, Mann-Whitney U test was used to confirm the difference between two groups.RESULTS:
Adhesion scores of Groups I, III and IV were significantly higher than in Group II. TNF-? levels were significantly higher in Groups I, III and IV. 5-HP levels were significantly lower in Groups I and II compared to Groups III and IV.CONCLUSION:
Based on these results, it appears that MB may prevent peritoneal adhesions in a peritonitis model, but wound healing could be impaired. MB should be further evaluated because of its dual effect.
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Base de dados:
MEDLINE
Assunto principal:
Peritonite
/
Aderências Teciduais
/
Colo
/
Azul de Metileno
/
Antioxidantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Ulus Travma Acil Cerrahi Derg
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Turquia