Pre-mRNA 3'-end processing complex assembly and function.
Wiley Interdiscip Rev RNA
; 2(3): 321-35, 2011.
Article
em En
| MEDLINE
| ID: mdl-21957020
ABSTRACT
The 3'-ends of almost all eukaryotic mRNAs are formed in a two-step process, an endonucleolytic cleavage followed by polyadenylation (the addition of a poly-adenosine or poly(A) tail). These reactions take place in the pre-mRNA 3' processing complex, a macromolecular machinery that consists of more than 20 proteins. A general framework for how the pre-mRNA 3' processing complex assembles and functions has emerged from extensive studies over the past several decades using biochemical, genetic, computational, and structural approaches. In this article, we review what we have learned about this important cellular machine and discuss the remaining questions and future challenges.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Precursores de RNA
/
Processamento de Terminações 3' de RNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev RNA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos