Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty.
Int Orthop
; 36(4): 703-9, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-21964703
ABSTRACT
PURPOSE:
Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA).METHODS:
Prospective randomised trials in which erythropoietin 15,000 IU was administered intravenously twice a week or 30,000 IU once a week (total 90,000 IU) combined with ferrous II sulphate (Ferro-Gradumet 2) orally and compared with Ferro-Gradumet 2 alone.RESULTS:
Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients.CONCLUSION:
We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue Autóloga
/
Cuidados Pré-Operatórios
/
Osteoartrite do Quadril
/
Eritropoetina
/
Artroplastia de Quadril
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int Orthop
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Croácia