Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus.
Clin Rheumatol
; 31(3): 435-40, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-21987229
ABSTRACT
We studied the levels of miR-146a and miR-155 in the urine sediment of SLE patients. The levels of miR-146a and miR-155 in the urine sediment of 40 SLE patients who were receiving calcitriol treatment and 13 healthy controls were determined with real-time quantitative polymerase chain reaction. The levels of urinary miR-146a and miR-155 in patients with SLE were significantly higher than that in healthy controls. Calcitriol treatment reduced the levels of urinary miR-155 in patients with SLE. The level of urinary miR-146a significantly correlated with estimated glomerular filtration rate (r = 0.242, P = 0.008). The level of urinary miR-155 significantly correlated with proteinuria (r = 0.407, P < 0.001) and systemic lupus erythematosus disease activity index (r = 0.278, P = 0.002). The level of urinary miR-146a reversely correlated with the urinary expression of TNF-α (r = -0.247, P = 0.012). Our results suggested that miR-146a and miR-155 might play important roles in the pathophysiology of SLE and the levels of urinary miR-146a and miR-155 could be used as potential markers for diagnosis, disease activity, and therapeutic response.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteinúria
/
MicroRNAs
/
Lúpus Eritematoso Sistêmico
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Rheumatol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China