Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals.
Zygote
; 21(3): 295-304, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-21993013
ABSTRACT
Ovarian folliculogenesis in mammals is a complex process. Several compounds have been tested during in vitro culture of follicular cells for a better understanding of the mechanisms and factors related to ovarian folliculogenesis in mammals. From these compounds, vascular endothelial growth factor (VEGF) can be highlighted, as it is strongly associated with angiogenesis and, in recent years, its presence in ovarian cells has been investigated extensively. Previous studies have shown that the presence of VEGF protein, as well as mRNA expression of its receptor 2 (VEGFR-2) increases during follicular development. Therefore, it is likely that the interaction between VEGF and VEGFR-2 is crucial to promote follicular development. However, few studies on the influence of this factor on follicular development have been reported. This review addresses aspects related to the structural characterization and mechanism of action of VEGF and its receptors, and their biological importance in the ovary of mammals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oócitos
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Ovário
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Fator A de Crescimento do Endotélio Vascular
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Zygote
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article