Macrophages in cancer and infectious diseases: the 'good' and the 'bad'.
Immunotherapy
; 3(10): 1185-202, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21995571
ABSTRACT
Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Imunoterapia
/
Infecções
/
Macrófagos
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunotherapy
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Itália