Executive dysfunction and treatment response in late-life depression.
Int J Geriatr Psychiatry
; 27(9): 893-9, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22009869
ABSTRACT
OBJECTIVES:
Executive dysfunction in geriatric depression has been shown to predict poor response to antidepressant medication. The purpose of this review is to clarify which aspects of executive functioning predict poor antidepressant treatment response.METHODS:
Literature review.RESULTS:
From our review, the aspects of executive functioning that appear to be associated with antidepressant response rates are verbal fluency and response inhibition. There is some indication that the semantic strategy component may account for the effects of verbal fluency, although evidence comes from one study and needs replication. Processing speed has been proposed as a substrate that may underlie the effects of executive dysfunction on treatment response. Although processing speed does not appear to account for the relationship between response inhibition and treatment outcome, this issue has yet to be assessed with respect to verbal fluency.CONCLUSIONS:
Verbal fluency and response inhibition are specific aspects of executive dysfunction that appear to impact antidepressant response rates. Disruption of the frontostriatal limbic circuit (particularly the anterior cingulate and dorsolateral prefrontal cortex) may explain the relation between these two mechanisms.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo
/
Função Executiva
/
Antidepressivos
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Int J Geriatr Psychiatry
Assunto da revista:
GERIATRIA
/
PSIQUIATRIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos