Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
J Immunol
; 187(9): 4392-402, 2011 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-22013205
ABSTRACT
Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Transativadores
/
Herpesvirus Saimiriíneo 2
/
Interleucina-17
/
Receptores de Interleucina-17
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos