Iron topochemistry and surface reactivity of amphibole asbestos: relations with in vitro toxicity.
Anal Bioanal Chem
; 402(2): 871-81, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22057722
ABSTRACT
Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe(2+) at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Ferrosos
/
Amiantos Anfibólicos
Limite:
Humans
Idioma:
En
Revista:
Anal Bioanal Chem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália