Serine protease autotransporters of enterobacteriaceae (SPATEs): biogenesis and function.
Toxins (Basel)
; 2(6): 1179-206, 2010 06.
Article
em En
| MEDLINE
| ID: mdl-22069633
ABSTRACT
Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Shigella flexneri
/
Proteínas de Bactérias
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Toxinas Bacterianas
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Escherichia coli
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Serina Proteases
Limite:
Animals
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Humans
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos