Contemporary insights into painful diabetic neuropathy and treatment with spinal cord stimulation.
Curr Pain Headache Rep
; 16(1): 43-9, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22071956
ABSTRACT
A substantial body of literature is available on the natural history of diabetes, but much less is understood of the natural history of painful diabetic peripheral neuropathy (PDPN), a pervasive and costly complication of diabetes mellitus. Multiple mechanisms have been proposed, including polyol pathway activation, advanced glycosylation end-product formation, and vasculopathic changes. Nevertheless, specific treatment modalities addressing these basic issues are still lacking. The mainstay of treatment includes pharmacological management with antidepressants, anticonvulsants, and opioids, but these drugs are often limited by unfavorable side-effect profiles. For over 30 years, spinal cord stimulation (SCS) has been used extensively for the management of various chronic neuropathic pain states. In the past decade, interest in the use of SCS for treatment of PDPN has increased. This article reviews pathophysiological mechanisms of PDPN, proposed mechanisms of SCS, and the role of SCS for the treatment of PDPN.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Terapia por Estimulação Elétrica
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Neuropatias Diabéticas
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Analgésicos Opioides
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Antidepressivos Tricíclicos
Limite:
Humans
Idioma:
En
Revista:
Curr Pain Headache Rep
Assunto da revista:
FISIOLOGIA
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos