Preventing progression to first-episode psychosis in early initial prodromal states.
Br J Psychiatry
; 200(1): 22-9, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22075649
ABSTRACT
BACKGROUND:
Young people with self-experienced cognitive thought and perception deficits (basic symptoms) may present with an early initial prodromal state (EIPS) of psychosis in which most of the disability and neurobiological deficits of schizophrenia have not yet occurred.AIMS:
To investigate the effects of an integrated psychological intervention (IPI), combining individual cognitive-behavioural therapy, group skills training, cognitive remediation and multifamily psychoeducation, on the prevention of psychosis in the EIPS.METHOD:
A randomised controlled, multicentre, parallel group trial of 12 months of IPI v. supportive counselling (trial registration number NCT00204087). Primary outcome was progression to psychosis at 12- and 24-month follow-up.RESULTS:
A total of 128 help-seeking out-patients in an EIPS were randomised. Integrated psychological intervention was superior to supportive counselling in preventing progression to psychosis at 12-month follow-up (3.2% v. 16.9%; P = 0.008) and at 24-month follow-up (6.3% v. 20.0%; P = 0.019).CONCLUSIONS:
Integrated psychological intervention appears effective in delaying the onset of psychosis over a 24-month time period in people in an EIPS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
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Psicologia do Esquizofrênico
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Terapia Cognitivo-Comportamental
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Educação de Pacientes como Assunto
/
Progressão da Doença
Tipo de estudo:
Clinical_trials
/
Observational_studies
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Prognostic_studies
Limite:
Adolescent
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Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha