Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.
J Infect Dis
; 205(1): 106-10, 2012 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-22075766
ABSTRACT
Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Meningites Bacterianas
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Infecções por Citomegalovirus
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Herpesvirus Humano 4
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Infecções por Vírus Epstein-Barr
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Citomegalovirus
/
Coinfecção
Tipo de estudo:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido