Connecting µ-fluidics to electron microscopy.
J Struct Biol
; 177(1): 128-34, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22094535
ABSTRACT
A versatile methodology for electron microscopy (EM) grid preparation enabling total content sample analysis is presented. A microfluidic-dialysis conditioning module to desalt or mix samples with negative stain solution is used, combined with a robotic writing table to micro-pattern the EM grids. The method allows heterogeneous samples of minute volumes to be processed at physiological pH for structure and mass analysis, and allows the preparation characteristics to be finely tuned.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microscopia Eletrônica de Transmissão e Varredura
/
Microfluídica
Limite:
Animals
Idioma:
En
Revista:
J Struct Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Suíça