Nanoparticle-based monitoring of cell therapy.
Nanotechnology
; 22(49): 494001, 2011 Dec 09.
Article
em En
| MEDLINE
| ID: mdl-22101191
ABSTRACT
Exogenous cell therapy aims to replace/repair diseased or dysfunctional cells and promises to revolutionize medicine by restoring tissue and organ function. To develop effective cell therapy, the location, distribution and long-term persistence of transplanted cells must be evaluated. Nanoparticle (NP) based imaging technologies have the potential to track transplanted cells non-invasively. Here we summarize the most recent advances in NP-based cell tracking with emphasis on (1) the design criteria for cell tracking NPs, (2) protocols for cell labeling, (3) a comparison of available imaging modalities and their corresponding contrast agents, (4) a summary of preclinical studies on NP-based cell tracking and finally (5) perspectives and future directions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
/
Rastreamento de Células
Tipo de estudo:
Guideline
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nanotechnology
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos