Multi-spot porous silicon chip prepared from asymmetric electrochemical etching for human immunoglobin G sensor.
J Nanosci Nanotechnol
; 11(8): 7061-4, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-22103124
ABSTRACT
Multi-spot porous silicon (MSPS)-based optical biosensor was developed to specify the biomolecules. MSPS chip was generated by an electrochemical etching of silicon wafer using an asymmetric electrode configuration in aqueous ethanolic HF solution and constituted with nine arrayed porous silicon. MSPS prepared from anisotropic etching conditions displayed the Fabry-Pérot fringe patterns which varied spatially across the porous silicon (PS). Each spot displayed different reflection resonances and different pore characteristics as a function of the lateral distance from the Pt counter electrode. The sensor system consists of the 3 x 3 spot array of porous silicon modified with Protein A. The system was probed with various fragments of an aqueous Human Immunoglobin G (Ig G) analyte. The sensor operated by measurement of the reflection patterns in the white light reflection spectrum of MSPS. Molecular binding and specificity was detected as a shift in wavelength of these Fabry-Pérot fringe patterns.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Eletroquímica
Limite:
Humans
Idioma:
En
Revista:
J Nanosci Nanotechnol
Ano de publicação:
2011
Tipo de documento:
Article