High cholesterol feeding may induce tubular dysfunction resulting in hypomagnesemia.
Kidney Blood Press Res
; 35(3): 137-46, 2012.
Article
em En
| MEDLINE
| ID: mdl-22104091
ABSTRACT
BACKGROUND/AIMS:
Hypomagnesemia may induce hypercholesterolemia, but the contrary has not been described yet. Thus, magnesium homeostasis was evaluated in rats fed a cholesterol-enriched diet for 8 days. This study has a relevant clinical application if hypomagnesemia, due to hypercholesterolemia, is confirmed in patients with long-term hypercholesterolemia.METHODS:
Both hypercholesterolemic (HC) and normocholesterolemic rats (NC) were divided into sets of experiments to measure hemodynamic parameters, physiological data, maximum capacity to dilute urine (C(H)((2))(O)), variations (Δ) in [Ca(2+)](i) and the expression of transporter proteins.RESULTS:
HC developed hypomagnesemia and showed high magnesuria in the absence of hemodynamic abnormalities. However, the urinary sodium excretion and C(H)((2))(O) in HC was similar to NC. On the other hand, the responses to angiotensin II by measuring Δ [Ca(2+)](i) were higher in the thick ascending limb of Henle's loop (TAL) of HC than NC. Moreover, high expression of the cotransporter NKCC2 was found in renal outer medulla fractions of HC. Taken together, the hypothesis of impairment in TAL was excluded. Actually, the expression of the epithelial Mg(2+) channel in renal cortical membrane fractions was reduced in HC.CONCLUSION:
Impairment in distal convoluted tubule induced by hypercholesterolemia explains high magnesuria and hypomagnesemia observed in HC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Erros Inatos do Transporte Tubular Renal
/
Colesterol na Dieta
/
Hipercalciúria
/
Hipercolesterolemia
/
Alça do Néfron
/
Nefrocalcinose
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Kidney Blood Press Res
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil