Staged gamma knife radiosurgery for large cerebral arteriovenous malformations.
Stereotact Funct Neurosurg
; 89(6): 365-71, 2011.
Article
em En
| MEDLINE
| ID: mdl-22104394
ABSTRACT
BACKGROUND:
We present our experience over a 10-year period of staged radiosurgery for large arteriovenous malformations (AVMs) including patient outcomes and methods.METHODS:
From July 2000 to December 2010, 80 patients with AVMs were treated with gamma knife radiosurgery (GKS) at our institution; of these patients, 5 were treated for large AVMs with staged GKS (volumes >20 cm(3)). The mean interval between treatments was 10 months (range 7-16). The mean dose for the margin used was 18.0 Gy (range 16-20). The mean volume treated was 37.2 cm(3) (range 22-50). The mean total follow-up was 76.5 months (range 42-120).RESULTS:
Two patients had complete obliteration of the AVM nidus. One patient had 95% obliteration (31 months after radiosurgery), one had 90% obliteration (38 months after radiosurgery), and one had less than 50% obliteration at 53 months with a 16-month interval between staged treatments.CONCLUSIONS:
Staged radiosurgery is an effective and safe method for the treatment of large AVMs. We report achieving higher marginal doses with staging in planned intervals of 6-9 months between staged treatments. It appears that the longer the wait between treatments, the less likely it is that complete obliteration will be achieved.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Malformações Arteriovenosas Intracranianas
/
Radiocirurgia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Stereotact Funct Neurosurg
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos