Crystallographic refinement of human serum retinol binding protein at 2A resolution.
Proteins
; 8(1): 44-61, 1990.
Article
em En
| MEDLINE
| ID: mdl-2217163
ABSTRACT
Human serum retinol binding protein (RBP) in complex with retinol has been crystallographically refined to an R-factor of 18.1% with 2A resolution data. The protein topology results in an anti-parallel beta-barrel that encapsulates the retinol ligand. A detailed description of the protein and the binding site is provided. Our structural work has helped to define a family of proteins, many of which are carrier proteins for smaller ligand molecules. We describe the structural basis for the conservation of sequence within the family.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao Retinol
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Proteins
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Suécia