The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells.
J Med Food
; 15(3): 242-52, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22181075
ABSTRACT
The rhizome of Curcuma longa (turmeric) is often used in Asia as a spice and as a medicine. Its most well-studied component, curcumin, has been shown to exhibit poor bioavailability in animal studies and clinical trials. We hypothesized that the presence of lipophilic components (e.g., turmerones) in turmeric extract would affect the absorption of curcumin. The effects of turmerones on curcumin transport were evaluated in human intestinal epithelial Caco-2 cells. The roles of turmerones on P-glycoprotein (P-gp) activities and mRNA expression were also evaluated. Results showed that in the presence of α- and aromatic turmerones, the amount of curcumin transported into the Caco-2 cells in 2 hours was significantly increased. α-Turmerone and verapamil (a P-gp inhibitor) significantly inhibited the efflux of rhodamine-123 and digoxin (i.e., inhibited the activity of P-gp). It is interesting that aromatic turmerone significantly increased the rhodamine-123 efflux and P-gp (MDR1 gene) mRNA expression levels. The effects of α- and aromatic turmerones on curcumin transport as well as P-gp activities were shown here for the first time. The presence of turmerones did affect the absorption of curcumin in vitro. These findings suggest the potential use of turmeric extract (including curcumin and turmerones), rather than curcumin alone, for treating diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
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Fármacos Gastrointestinais
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Membro 1 da Subfamília B de Cassetes de Ligação de ATP
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Enterócitos
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Curcumina
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Absorção Intestinal
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Antineoplásicos Fitogênicos
Idioma:
En
Revista:
J Med Food
Assunto da revista:
CIENCIAS DA NUTRICAO
/
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China