Epigenetics and the environment: emerging patterns and implications.
Nat Rev Genet
; 13(2): 97-109, 2012 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-22215131
ABSTRACT
Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable chromatin modifications. There has been considerable interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and could thereby influence gene expression and phenotype. Chemical pollutants, dietary components, temperature changes and other external stresses can indeed have long-lasting effects on development, metabolism and health, sometimes even in subsequent generations. Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems. These have implications for structuring future research and understanding disease and development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
/
Interação Gene-Ambiente
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2012
Tipo de documento:
Article