Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes.
Biotechnol Lett
; 34(5): 805-12, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22215377
ABSTRACT
Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
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Glicoproteínas de Membrana
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Proteínas Quinases Dependentes de AMP Cíclico
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Oxirredutases Intramoleculares
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Inibidores de Proteínas Quinases
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Diterpenos
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Lactonas
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Melanócitos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biotechnol Lett
Ano de publicação:
2012
Tipo de documento:
Article