Altered placental methyl donor transport in the dexamethasone programmed rat.
Placenta
; 33(3): 220-3, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22226642
ABSTRACT
There is increasing evidence for a role for epigenetic modifications in early life 'programming' effects. Altered placental methyl donor transport may impact on the establishment of epigenetic marks in the fetus. This study investigated the effects of prenatal glucocorticoid overexposure on placental methyl donor transport. Glucocorticoids increased folate but decreased choline transport and reduced fetal plasma methionine levels. There was no change in global DNA methylation in fetal liver. These data suggest prenatal glucocorticoid overexposure causes complex alterations in the placental transport of key methyl donors which may have important implications for maternal diet and nutrient supplementation in pregnancy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Dexametasona
/
Desenvolvimento Embrionário
/
Metano
Tipo de estudo:
Evaluation_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Placenta
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido