Potential variant of multiple endocrine neoplasia in a dog.
J Am Anim Hosp Assoc
; 48(2): 132-8, 2012.
Article
em En
| MEDLINE
| ID: mdl-22267170
ABSTRACT
This report describes multiple endocrine neoplasia in a dog, which is a rare hereditary disorder characterized by the presence of two or more neoplasms of different endocrine tissues within a patient. A 14 yr old dog was evaluated for polyuria/polydipsia, polyphagia, and abdominal enlargement. Adrenal-dependent hyperadrenocorticism with concomitant left thyroid enlargement and a presumed abdominal metastatic lesion were diagnosed by an adrenocorticotropic hormone stimulation test, ultrasonography, and computed tomography. Trilostane therapy was initiated and resolved the clinical signs for 2 yr at which time the dog presented with left testicular enlargement. The dog was euthanized and was diagnosed with adrenocortical carcinoma, thyroid carcinoma, an abdominal mass compatible with a metastatic lymph node, and bilateral interstitial cell testicular adenomas. To the authors' knowledge, this is the first report to describe the concomitant association of these types of endocrine neoplasms in a dog. The concomitant presence of these neoplasms could represent a potential variant of multiple endocrine neoplasia; however, the presence of the interstitial cell testicular adenomas may have only been an incidental finding. If any of these tumors are diagnosed, veterinarians should perform a thorough clinical assessment to evaluate for the presence of additional endocrine neoplasms or hyperplasia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasia Endócrina Múltipla
/
Doenças do Cão
Limite:
Animals
Idioma:
En
Revista:
J Am Anim Hosp Assoc
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália