Myoblast fusion: lessons from flies and mice.
Development
; 139(4): 641-56, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22274696
ABSTRACT
The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a large volume of cytoplasm. Principles learned from the study of myoblast fusion not only enhance our understanding of myogenesis, but also contribute to our perspectives on membrane fusion and cell-cell fusion in a wide array of model organisms and experimental systems. Recent studies have advanced our views of the cell biological processes and crucial proteins that drive myoblast fusion. Here, we provide an overview of myoblast fusion in three model systems that have contributed much to our understanding of these events the Drosophila embryo; developing and regenerating mouse muscle; and cultured rodent muscle cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fusão Celular
/
Mioblastos
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Drosophila
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Camundongos
Limite:
Animals
Idioma:
En
Revista:
Development
Assunto da revista:
BIOLOGIA
/
EMBRIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos