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Recombinant dengue type 2 viruses with altered e protein domain III epitopes are efficiently neutralized by human immune sera.
Wahala, Wahala M P B; Huang, Claire; Butrapet, Siritorn; White, Laura J; de Silva, Aravinda M.
Afiliação
  • Wahala WM; Address correspondence to Aravinda M. de Silva, desilva@med.unc.edu.
J Virol ; 86(7): 4019-23, 2012 Apr.
Article em En | MEDLINE | ID: mdl-22278250
Humans develop polyclonal, serotype-specific neutralizing antibody responses after dengue virus (DENV) infection. Many mouse antibodies that neutralize DENV bind to the lateral ridge or A strand epitopes on domain III of the viral envelope (EDIII) protein. It has been assumed that these epitopes are also the main target of human neutralizing antibodies. Using recombinant dengue serotype 2 viruses with altered EDIII epitopes, we demonstrate that EDIII epitopes are not the main target of human neutralizing antibody.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Dengue / Vírus da Dengue / Anticorpos Neutralizantes / Soros Imunes / Epitopos Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Dengue / Vírus da Dengue / Anticorpos Neutralizantes / Soros Imunes / Epitopos Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2012 Tipo de documento: Article