Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.
J Nat Prod
; 75(2): 257-61, 2012 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-22304006
ABSTRACT
Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Cumarínicos
/
Zanthoxylum
/
Células-Tronco Neurais
/
Antineoplásicos Fitogênicos
Limite:
Animals
/
Humans
País/Região como assunto:
America do sul
/
Paraguay
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França