Superior immunogenicity of a freeze-dried, cell culture-derived Japanese encephalitis vaccine (inactivated).
Vaccine
; 30(13): 2329-35, 2012 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-22306856
ABSTRACT
Japanese encephalitis is an infectious disease caused by the Japanese encephalitis virus, which is widespread throughout Asia. The worldwide incidence is 50,000 cases per year. There is no specific treatment available, but inactivated mouse brain-derived vaccine was used from the 1950s to prevent infection. However, quality control of mouse brain-derived vaccines is difficult, and therefore a new freeze-dried, cell culture-derived Japanese encephalitis vaccine (inactivated) (JEBIK V; development code BK-VJE) was developed. In this paper, we report an analysis of neutralizing antibody titers in vaccinated subjects enrolled in clinical study of BK-VJE at various doses, and study of BK-VJE with the mouse brain-derived vaccine as a control. The results show that BK-VJE has superior immunogenicity compared to mouse brain-derived vaccine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas de Produtos Inativados
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Encefalite Japonesa
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Vacinas contra Encefalite Japonesa
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Vírus da Encefalite Japonesa (Espécie)
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Anticorpos Neutralizantes
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Liofilização
Limite:
Animals
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Child
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Child, preschool
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Humans
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Infant
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão