P190 BCR/ABL transcript in a case of Philadelphia-positive multiple myeloma.
Leukemia
; 4(11): 751-4, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-2232886
ABSTRACT
Philadelphia positive multiple myeloma is a very rare event and, so far, no molecular data about the involvement of the BCR and C-ABL genes are available. We report here the case of a 64-year-old woman presenting with a typical multiple myeloma and a complex Philadelphia (Ph) chromosome that we investigated at a molecular level using conventional DNA techniques and the polymerase chain reaction (PCR). No rearrangement was observed within the major breakpoint cluster region (M-BCR) although she was found to have a P190 BCR/ABL hybrid transcript using PCR. As far as we know, this is the first description of a P190-type mRNA in a patient with a chronic lymphoid disorder. Since P190 is almost always associated in man with acute forms of hematological malignancies, this suggests that other factors may play a role in determining the phenotype of the disease.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomo Filadélfia
/
RNA Mensageiro
/
Proteínas de Fusão bcr-abl
/
Mieloma Múltiplo
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Leukemia
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Bélgica