Physangulidines A, B, and C: three new antiproliferative withanolides from Physalis angulata L.
Org Lett
; 14(5): 1230-3, 2012 Mar 02.
Article
em En
| MEDLINE
| ID: mdl-22329497
ABSTRACT
Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Magnoliopsida
/
Vitanolídeos
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Antineoplásicos Fitogênicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos