Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth.
Mol Cell Biochem
; 364(1-2): 235-41, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22350753
ABSTRACT
Accumulated evidence suggests a major role for the activation of the Sonic Hedgehog (SHH) signaling pathway in the development of neural crest stem cells that give rise to the sympathetic nervous system. We therefore investigated the involvement of SHH signaling in the pathogenesis of neuroblastoma (NB), a common childhood malignant tumor of the sympathetic nervous system. Inhibition of SHH signaling by cyclopamine induced apoptosis and blocked proliferation in all major types of NB cells, and abrogated the tumorigenicity of NB cells. Our study has revealed a molecular mechanism for the persistent activation of the SHH pathway which promotes the development of NB, and suggests a new approach for the treatment of this childhood malignant tumor.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Neoplasias de Tecido Nervoso
/
Proteínas Hedgehog
/
Neuroblastoma
Limite:
Humans
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China