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Effects of prolonged-release melatonin and zolpidem on postural stability in older adults.
Otmani, Sarah; Metzger, Deborah; Guichard, Nathalie; Danjou, Philippe; Nir, Tali; Zisapel, Nava; Katz, Amnon.
Afiliação
  • Otmani S; Forenap Pharma, Rouffach, France.
Hum Psychopharmacol ; 27(3): 270-6, 2012 May.
Article em En | MEDLINE | ID: mdl-22350925
OBJECTIVES: A prolonged-release formulation of melatonin (PR-M) is indicated for insomnia in patients aged 55 years and older. Because hypnotics result in impairments of body sway, it was important to evaluate the effect of 2 mg PR-M on postural stability in older adults at night. METHODS: Twenty-four healthy volunteers (12 women, 12 men, aged 55-64 years) completed a randomized, double-blind, single-dose, three-way crossover study of postural stability of PR-M 2 mg, zolpidem 10 mg (active control) or placebo. Subjects were tested for body sway 30 min before, 1.5 and 4 h after dosing. Parameters tested were the area of the 95% confidence ellipse enclosing the center of pressure (COP; [A95]) and COP path length. RESULTS: Zolpidem significantly increased the A95 (both eyes conditions at all time points) and path length of COP. PR-M had no effect on A95 (both "eyes closed" and "eyes open" conditions at all time points) compared with placebo and increased COP path length by 10% at 4 h post-dose in open but not closed eyes condition. No serious adverse events were observed. CONCLUSIONS: In older adults, evening PR-M intake did not impair postural stability during the night. The postural instability with zolpidem demonstrated assay sensitivity and validated the outcome.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Sistemas de Liberação de Medicamentos / Equilíbrio Postural / Hipnóticos e Sedativos / Melatonina / Antioxidantes Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Hum Psychopharmacol Assunto da revista: PSICOFARMACOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Sistemas de Liberação de Medicamentos / Equilíbrio Postural / Hipnóticos e Sedativos / Melatonina / Antioxidantes Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Hum Psychopharmacol Assunto da revista: PSICOFARMACOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: França