Clinical significance of diffuse hepatic visualization and thyroid bed uptake on post-ablative iodine-131 whole body scan in differentiated thyroid cancer.
Onkologie
; 35(3): 82-6, 2012.
Article
em En
| MEDLINE
| ID: mdl-22414970
ABSTRACT
BACKGROUND:
The aim of this study was to investigate whether diffuse hepatic and thyroid bed uptake of (131)I on post-ablative whole body scans (PAWBS) of patients with differentiated thyroid cancer (DTC) have any relevance for clinical outcome and parameters. PATIENTS ANDMETHODS:
We retrospectively reviewed 838 patients with DTC, who were treated at Pusan National University Hospital from 2004 to 2009. Grades of hepatic and thyroid bed uptake on (131)I whole body scan were classified from 0 to 3 by visual assessment. Recurrence-free survival was evaluated with the Kaplan-Meier method and Cox regression analysis.RESULTS:
Male patients having tumors larger than 4 cm (p = 0.005), multiple tumor foci (p < 0.001), involved margins (p = 0.006), and a higher TNM stage (p < 0.001) were more likely to relapse. Thyroid bed grade (p < 0.001) and liver uptake grade (p = 0.002) were also revealed as significant prognostic factors. Intense thyroid bed uptake and faint hepatic activity were related to poor prognosis.CONCLUSIONS:
We suggest that increased retention of (131)I in the thyroid bed and less visualization of liver on PAWBS mean poor prognosis. This would be related to the amount of remnant thyroid tissue and ineffective destruction of it.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
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Neoplasias da Glândula Tireoide
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Imagem Corporal Total
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Radioisótopos do Iodo
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Fígado
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Onkologie
Ano de publicação:
2012
Tipo de documento:
Article