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Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism.
Tostes, M H F S; Teixeira, H C; Gattaz, W F; Brandão, M A F; Raposo, N R B.
Afiliação
  • Tostes MH; NUPICS/NIQUA, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Pharmacopsychiatry ; 45(6): 241-3, 2012 Sep.
Article em En | MEDLINE | ID: mdl-22426848
ABSTRACT

INTRODUCTION:

Modifications in neurotrophins, neuropeptides, cytokines and nitric oxide (NO) levels in autism may represent different biological aspects of the disease. In the present study we investigate simultaneously all these variables as an attempt to clarify their interrelationships in autism.

METHODS:

Plasma levels of vasoactive intestinal peptide (VIP), neurotrophin-3 (NT-3), cytokines and nitric oxide (NO) were determined in children with DSM-IV autistic disorder (n = 24) and in age- and gender-matched healthy controls (n = 24). VIP, NT-3, IFN-γ and IL-1ß levels were measured by ELISA, TNF-α, IL-10, IL-6, IL-4, IL-2 were evaluated by fl ow cytometry, and NO by Griess reaction.

RESULTS:

Plasma levels of VIP, IFN-γ and NO were significantly higher and NT-3 plasma levels were significantly lower in children with autism, compared to the healthy subjects. In children with autism there was a positive correlation between plasma levels of NO and IFN-γ.

DISCUSSION:

Our results indicate the presence of altered levels of neurotrophin and neuropeptide in infantile autism and provide additional evidence that higher levels of IFN-γ may be associated with increased oxidative stress in autism.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Peptídeo Intestinal Vasoativo / Citocinas / Interferon gama / Neurotrofina 3 / Óxido Nítrico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Pharmacopsychiatry Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Peptídeo Intestinal Vasoativo / Citocinas / Interferon gama / Neurotrofina 3 / Óxido Nítrico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Pharmacopsychiatry Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil