Carbon nanotubes promote growth and spontaneous electrical activity in cultured cardiac myocytes.
Nano Lett
; 12(4): 1831-8, 2012 Apr 11.
Article
em En
| MEDLINE
| ID: mdl-22432413
ABSTRACT
Nanoscale manipulations of the extracellular microenvironment are increasingly attracting attention in tissue engineering. Here, combining microscopy, biological, and single-cell electrophysiological methodologies, we demonstrate that neonatal rat ventricular myocytes cultured on substrates of multiwall carbon nanotubes interact with carbon nanotubes by forming tight contacts and show increased viability and proliferation. Furthermore, we observed changes in the electrophysiological properties of cardiomyocytes, suggesting that carbon nanotubes are able to promote cardiomyocyte maturation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Miócitos Cardíacos
/
Nanotubos de Carbono
Limite:
Animals
Idioma:
En
Revista:
Nano Lett
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália