Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of Nigrofomes melanoporus and their cytotoxicity.
Planta Med
; 78(7): 737-9, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22437245
ABSTRACT
Two new drimane-type compounds, nigrofomins A ( 1) and B ( 2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A ( 1) and B ( 2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC (50) values in the range of 99.44-246.32 µM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G (0)/G (1) phase.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Leucemia-Linfoma Linfoblástico de Células T Precursoras
/
Antineoplásicos Fitogênicos
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Taiwan