Prevalence of transcranial Doppler abnormalities in Nigerian children with sickle cell disease.
Am J Hematol
; 87(5): 544-7, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22460323
ABSTRACT
Transcranial Doppler (TCD) ultrasonography helps to identify children with sickle cell disease (SCD) who are at an increased risk of stroke,making primary stroke prevention a reality. A cross-sectional study of145 Nigerian children aged ≥3 years with SCD was carried out to describe the pattern of cerebral blood flow (CBF) abnormalities. The mean time-averaged mean velocity (TAMV) was 152 ±27.0 cm/sec and122 ±22.0 cm/sec in Hb SS and Hb S1C group, respectively. Abnormal velocities were recorded in six (4.7%) of the Hb SS patients and none of the Hb S1C while conditional risk (CR) velocities were recorded in 19.7% of Hb SS (low conditional 11.0%, high conditional 8.7%) and low conditional in 5.6% of Hb S1C cases. Cerebral flow velocities showed a negative correlation with age and hematocrit. Compared with African-American children, Nigerian children with Hb SS disease have a considerably higher prevalence of CR velocities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Artérias Cerebrais
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Circulação Cerebrovascular
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Acidente Vascular Cerebral
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Anemia Falciforme
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Am J Hematol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Nigéria