Liver failure caused by light chain deposition disease associated with multiple myeloma.
Intern Med
; 51(7): 773-6, 2012.
Article
em En
| MEDLINE
| ID: mdl-22466837
ABSTRACT
Acute liver failure is an unusual complication in multiple myeloma. Here, we report a case of multiple myeloma with light chain deposition disease (LCDD) that presented with progressive jaundice due to intrahepatic cholestasis. Diagnosis was made after liver biopsy that showed deposition of kappa light chains occupying perisinusoidal spaces. The patient developed encephalopathy and liver failure and died despite prompt initiation of dexamethasone therapy. The current prognosis of multiple myeloma patients with liver failure due to LCDD is dismal. New therapeutic strategies might improve this condition.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Cadeias kappa de Imunoglobulina
/
Falência Hepática Aguda
/
Mieloma Múltiplo
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha