Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes.
Nat Immunol
; 13(5): 511-8, 2012 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-22473038
ABSTRACT
Innate γδ T cells function in the early phase of immune responses. Although innate γδ T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, γδ effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of γδ effector cells. A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γδ effector cells in the thymus. The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Diferenciação Celular
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Subpopulações de Linfócitos T
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Receptores de Antígenos de Linfócitos T gama-delta
/
Transcriptoma
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos