25-hydroxyvitamin D levels and vascular calcification in predialysis and dialysis patients with chronic kidney disease.
Kidney Blood Press Res
; 35(5): 349-54, 2012.
Article
em En
| MEDLINE
| ID: mdl-22487876
ABSTRACT
BACKGROUND/AIMS:
The role of vitamin D in the process of vascular calcification is unclear in patients with chronic kidney disease. We investigated whether serum 25-hydroxyvitamin D [25(OH)D] is associated with vascular calcification in predialysis and dialysis patients.METHODS:
We included 86 predialysis and 139 dialysis patients. The simple vascular calcification score (SVCS) was evaluated by examining plain X-rays of the pelvis and hands as described previously. The carotid-to-femoral pulse wave velocity (CF-PWV) was assessed with a commercially available device.RESULTS:
We found a high prevalence of vitamin D deficiency in our population (78.2%). Vascular calcification was present in 46.2% of all patients. Higher calcification (SVCS >3) was significantly associated with lower 25(OH)D levels in predialysis and dialysis patients. Multiple logistic regression analysis for SVCS >3 showed that 25(OH)D levels were negative independent predictors in predialysis (OR 0.781; 95% CI 0.623-0.908, p = 0.019) and dialysis patients (OR 0.805; 95% CI 0.749-0.853, p = 0.009). Lower 25(OH)D levels were associated with higher CF-PWV in predialysis patients, but this inverse relationship was no longer present in multivariate analysis.CONCLUSION:
We showed an independent relationship between low serum 25(OH)D levels and vascular calcification in both predialysis and dialysis patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
/
Vitamina D
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Deficiência de Vitamina D
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Calcinose
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Diálise Renal
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Insuficiência Renal Crônica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
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Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Kidney Blood Press Res
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Coréia do Sul