[Phenotypic differences of stroma cells in benign and malignant human prostate tissues].
Zhonghua Yi Xue Za Zhi
; 92(8): 516-9, 2012 Feb 28.
Article
em Zh
| MEDLINE
| ID: mdl-22490152
ABSTRACT
OBJECTIVE:
To analyze the stroma changes of benign and malignant human prostate tissues.METHODS:
For the identification of stroma cells phenotype in human prostate cancer and benign prostate hyperplasia tissues, Masson method and immunohistochemical analysis of α-smooth muscle actin (α-SMA), desmin, and vimentin were performed. The relative volume of intratumor stroma (0%, Grade 0; 1% - 33%, Grade 1; 34% - 66%, Grade 2; 67% - 100%, Grade 3) were quantified and analyzed in local and advanced prostate cancer tissues.RESULTS:
Stroma myofibroblasts in prostate cancer were stained green by Masson staining and showed a co-expression of α-SMA and vimentin without an expression of desmin. It was significantly different from smooth muscle cells in benign prostate hyperplasia stained red and co-expressing a-SMA and desmin. Statistical analysis showed that high stroma volume (Grade 2/3) in advanced prostate cancer were significantly higher than that in an early stage of prostate cancer (83% vs 55%, P < 0.05).CONCLUSION:
Significant phenotypic differences of stroma cells existed in benign and malignant human prostate tissues. A high expression of myofibroblasts in advanced prostate cancer may play an important role in cancer progression. And its clinical significance should raise a high alert.
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Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Hiperplasia Prostática
/
Neoplasias da Próstata
/
Células Estromais
Limite:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China