Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Bioorg Med Chem Lett
; 22(10): 3535-9, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22503249
ABSTRACT
A series of thirty-three thymol, p-cymene-3-carboxylic acid, and 3-amino-p-cymene derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV3 channels. Most of them acted as strong modulators of TRPA1, TRPM8, and TRPV3 channels with EC(50) and/or IC(50) values distinctly lower than those of thymol and related monoterpenoids. Some of the compounds examined, that is, 3c, 4e, f, 6b, and 8b exhibited an appreciable subtype-selectivity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timol
/
Canais de Potencial de Receptor Transitório
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália