Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes.
Bioorg Med Chem
; 20(10): 3323-31, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22512908
ABSTRACT
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ(1), σ(2)-receptors and sodium channels binding affinity of compounds 2 were investigated. One of the most active analogs, 2a, had an interesting in vivo anticancer profile against the BxPC-3 and Mia-Paca-2 pancreas cancer cell lines with caspase-3 activation, which was associated with an anagelsic activity against the neuropathic pain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adamantano
/
Receptores sigma
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Grécia