No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis.
Mult Scler
; 18(12): 1791-6, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22513520
ABSTRACT
OBJECTIVE:
Chronic cerebrospinal venous insufficiency (CCSVI) was hypothesized to play a causative role in multiple sclerosis (MS). The assessment of pediatric-onset MS (POMS) may provide a unique window of opportunity to study hypothesized risk factors in close temporal association with the onset of the disease.METHODS:
Internal jugular veins, vertebral veins and intracranial veins were evaluated with extracranial and intracranial ultrasound in 15 POMS and 16 healthy controls. Assessor's blinding was maintained during the study. We considered subjects positive to CCSVI when at least two criteria were fulfilled.RESULTS:
CCSVI frequency was comparable between POMS and controls (p > 0.05). Clinical features were not significantly different between CCSVI-positive and CCSVI-negative patients.CONCLUSIONS:
Our findings add to previous data pointing against a causative role of CCSVI in MS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Insuficiência Venosa
/
Encéfalo
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mult Scler
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália