Synthesis and antimicrobial evaluation of some pyrazole derivatives.
Molecules
; 17(5): 4962-71, 2012 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-22547318
ABSTRACT
Reaction of a series of (E)-3-phenyl-4-(p-substituted phenyl)-3-buten-2-ones with p-sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the other hand, refluxing of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide in ethanol containing a few drops of acetic acid gave pyrazoline-1-thiocarboxamides and isonicotinoyl pyrazolines, respectively. The structures of the synthesized compounds were determined on the basis of their elemental analyses and spectroscopic data. The antimicrobial activity of the newly isolated heterocyclic compounds was evaluated against Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed a moderate degree of potent antimicrobial activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Fungos
/
Bactérias Gram-Negativas
/
Bactérias Gram-Positivas
/
Antibacterianos
/
Antifúngicos
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Egito