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Instituto Evandro Chagas

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[The current and future approaches to the treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)].

Yamano, Yoshihisa; Sato, Tomoo; Ando, Hitoshi; Araya, Natsumi; Yagishita, Naoko.
Nihon Rinsho; 70(4): 705-13, 2012 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-22568157
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that is the causative agent of a progressive neurological disease termed HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is a chronic neuroinflammatory disease characterized by spastic paraparesis, lower limb sensory disturbance and bladder/bowel dysfunction. Over the twenty-five years since the discovery of this disease, significant advancements have been made in the pathogenic mechanisms associated with HAM/TSP, however, little progress has been made in the treatment of this disorder. This review highlights the natural history of HAM/TSP, informative results of clinical trials, and discusses the current and future approaches to the treatment of HAM/TSP within the context of our understanding of the underlying pathogenic mechanisms.