Decisional procalcitonin thresholds are not adapted to elderly patients admitted to the emergency room.
Biomarkers
; 17(5): 477-81, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22607374
ABSTRACT
CONTEXT Diagnosis of sepsis in elderly is challenging. OBJECTIVES:
We investigated whether procalcitonin concentrations in elderly differed from values for the general population.METHODS:
Procalcitonin measurement was assessed prospectively in 307 apyretic patients ≥75 years visiting the emergency department.RESULTS:
Median age was 86 years [IQR81-90] and 222 (72%) were female. Procalcitonin concentration was 0.057 µg/L [0.040-0.092]; 99th percentile was 0.661 µg/L. Patients with procalcitonin concentrations above decisional thresholds had lower glomerular filtration rate and higher C-reactive protein concentrations.CONCLUSIONS:
Baseline procalcitonin levels are increased in elderly. Elevated values are common and associated to low-grade inflammation and lower eGFR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Proteína C-Reativa
/
Calcitonina
/
Serviço Hospitalar de Emergência
/
Taxa de Filtração Glomerular
Tipo de estudo:
Observational_studies
Limite:
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biomarkers
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França