Brain imaging findings in symptomatic patients after allogeneic haematopoietic stem cell transplantation: correlation with clinical outcome.
Eur Radiol
; 22(10): 2273-81, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22618523
ABSTRACT
OBJECTIVE:
To investigate the risk factors for, and the incidence of, structural abnormalities on brain imaging in allogeneic haematopoietic stem cell transplant (HSCT) patients, and correlate these findings with survival.METHODS:
We retrospectively reviewed all brain computed tomography (CT) and/or magnetic resonance imaging (MRI) studies obtained during the first post-HSCT year from 2004 thru 2007 in allogeneic HSCT recipients.RESULTS:
A total of 128 patients had brain imaging in the first post-HSCT year. Forty one of these 128 patients (32 %) had structural abnormalities on brain imaging cerebrovascular complications (n = 10), central nervous system (CNS) infection (n = 9), subdural fluid collection (n = 6), CNS recurrence of haematological malignancy (n = 11), and drug toxicity abnormalities (n = 5). The only significant risk factor for structural imaging abnormality was younger patient age (P = 0.01). MRI was significantly more likely than CT to provide specific imaging diagnosis of cerebral lesions (P = 0.001). HSCT patients with cerebrovascular complications have poor survival (P < 0.05). However, overall survival was not significantly worse for the 41 patients with the structural imaging abnormalities as compared to the 87 patients who had brain imaging but no structural abnormalities.CONCLUSIONS:
There was no survival difference in patients whose brain imaging was normal or abnormal. However, there was poor outcome in patients with cerebrovascular complications after HSCT. KEY POINTS ⢠Brain imaging frequently demonstrates neurological complications following haematopoietic stem cell transplantation. ⢠Younger HSCT patients are more likely to exhibit abnormal brain imaging findings. ⢠HSCT recipients with cerebrovascular complications have the worst survival. ⢠However brain imaging results are weak indicators of overall survival after HSCT.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
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Imageamento por Ressonância Magnética
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Tomografia Computadorizada por Raios X
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Transplante de Células-Tronco Hematopoéticas
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Neuroimagem
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos