An inhibitor of protein synthesis initiation from Alhagi kirgisorum S.
FEBS Lett
; 275(1-2): 99-101, 1990 Nov 26.
Article
em En
| MEDLINE
| ID: mdl-2262008
ABSTRACT
Polyproanthocyanidin--a plant phenolic compound from Alhagi kirgisorum S. effectively inhibited protein synthesis in rabbit reticulocyte and wheat germ cell-free systems. Poly-proanthocyanidin inhibited translation only at the level of initiation and not at the elongation level and aminoacylation of tRNA. The inhibitory effect of the phenolic compound is due to the blockage of the ternary complex formation of eIF-2 with GTP and initiator Met-tRNA.
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Base de dados:
MEDLINE
Assunto principal:
Iniciação Traducional da Cadeia Peptídica
/
Fenóis
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1990
Tipo de documento:
Article