ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos.
Dev Dyn
; 241(8): 1325-32, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22639388
ABSTRACT
BACKGROUND:
The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families.RESULTS:
Here we identify a novel chick gene with close homology to double-stranded RNA-binding protein Interleukin enhancer binding factor 3 (ILF-3) in other species. Our results show that chick Ilf-3 is required for proper expression of the transcription factor, Zic-1, at the neural plate border.CONCLUSION:
We have identified a novel chick gene and show it has a role in the correct specification of Zic-1 at the neural plate border.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas do Fator Nuclear 90
/
Placa Neural
/
Crista Neural
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Dev Dyn
Assunto da revista:
ANATOMIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos